Festivalen ble arrangert fra 12 Mar til 20 Mar 2010 (8 dag(er)).
South By Southwest (SXSW) finner sted i Austin, United States. Her er den fullstendige adressen til festivalen: Austin Convention Center, Austin, TX, US 78701
Imagine Dragons, Muse, Sum 41, Pierce the Veil, Asking Alexandria, Band of Horses, The Revivalists, Cheap Trick, Bowling for Soup, First Aid Kit, No Te Va Gustar, Stone Temple Pilots, John Hiatt, Mads Langer, We Came as Romans, Marina, Billy Bragg, GWAR, Smokey Robinson, Metric, Of Mice & Men, Circa Survive, Animals as Leaders, Fitz and The Tantrums, Bury Tomorrow.
De mest populære sjangrene og undersjangrene i den siste utgaven var:
rock
pop
punk
indie
indie rock
alternative
alternative rock
indie pop
metal
experimental
hardcore
emo
hard rock
metalcore
post-hardcore
americana
punk rock
pop rock
acoustic